The most cost-effective process for producing heavy water is the Girdler sulfide process. Heavy water can be toxic to humans, but a large amount would be needed for poisoning to occur.ĭeuterated water (HDO) occurs naturally in normal water and can be separated through distillation, electrolysis, or chemical exchange processes. However, some prokaryotes like bacteria can survive in a heavy hydrogen environment. It can be lethal to multicellular organisms at concentrations over 50%. Heavy water affects biological systems by altering enzymes, hydrogen bonds, and cell division in eukaryotes. It is not radioactive in its pure form, but it can become slightly radioactive when used as a coolant in nuclear reactors. While it has no significant taste difference, it can taste slightly sweet. Heavy water is less dissociated at a given temperature, and it does not have the blue color of regular water. Tritiated water is radioactive due to tritium content.ĢO) has different physical properties than regular water, such as being 10.6% denser and having a higher melting point. Semiheavy water (HDO) is more common than pure heavy water, while heavy-oxygen water is denser but lacks unique properties. Heavy water contains deuterium atoms and is used in nuclear reactors. The presence of the heavier hydrogen isotope gives the water different nuclear properties, and the increase in mass gives it slightly different physical and chemical properties when compared to normal water.ĭeuterium is a heavy hydrogen isotope. H or H, also called protium) that makes up most of the hydrogen in normal water. H or D, also known as heavy hydrogen) rather than the common hydrogen-1 isotope ( 1 2O) is a form of water whose hydrogen atoms are all deuterium ( 2
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When treating sound errors in children, clinicians attempt to effect the greatest amount of change in the child's phonological system with the least amount of teaching ( Gierut, 1998). However, in our well-intentioned efforts to distinguish difference from disorder, speech-language pathologists may be overlooking effective approaches for accent modification simply because those approaches are already associated with the remediation of speech disorders in children. In this framework, clinical experience, published empirical research, and client values act as drivers of best practice ( Kamhi, 2006). This clinical rigor is encapsulated in the framework of evidence-based practice. Regardless of this distinction, the same clinical rigor applied to the treatment of speech disorders should also be applied to accent modification services ( Franklin & Stoel-Gammon, 2014 Levy & Crowley, 2012 Muller, Ball, Guendouzi, & Muller, 2000 Sikorski, 2005). ASHA clearly states that foreign accents demonstrate speech differences rather than speech disorders ( ASHA, 1997). In fact, depending on the clinical population served, some speech-language pathologists may benefit from receiving accent modification if they plan to provide services outside of their native language community ( Levy & Crowley, 2012).Īccent modification is an acknowledged area of clinical practice for speech-language pathologists ( American Speech-Language-Hearing Association, 1997 Derwing & Munro, 2005 Sikorski, 2005). In such cases, nonnative speakers may elect to receive accent modification from teachers of English to speakers of other languages or speech-language pathologists to improve their communication skills. However, there are times when interference between a speaker's native language (NL) and target language (TL) does result in reduced intelligibility and comprehensibility ( Bresnahan, Ohashi, Nebashi, Liu, & Shearman, 2002 Trofimovich & Isaacs, 2012). Speaking with a foreign accent does not automatically lead to communication difficulties such as low intelligibility or comprehensibility ( Derwing & Munro, 1997, 2009). Gluszek and Dovidio (2010) demonstrated that speakers with strong foreign accents reported more difficulties with communication and a higher perception of stigmatization from others than did individuals with mild accents. A study by Munro (2003) identified stereotyping, harassment, and job discrimination as some of the negative social consequences experienced by English language learners (ELLs). Some nonnative speakers of English may experience negative social and professional consequences as a result of their foreign-accented speech ( Deprez-Sims & Morris, 2010). Most adults who learn a new language will speak that language with a noticeable foreign accent ( Flege, Munro, & MacKay, 1995 Scovel, 2000). For example, you could generate 20 random words and then incorporate all of them into a story. This tool can be a great way to generate creative writing ideas. This will place them in the "Your Word List" area and you can build a new list that meets your needs.īelow you'll find some of the common ways this tool can be used. You can use this list or you can scan them and choose the ones you want to keep by clicking on them. Once done, you simply press the "Generate Random Words" button and a list of words will appear. You can choose from all words, verbs only, nouns only or adjective only depending on which best meets your needs. All you need to do is choose the number of words you want to create (the default is five, but you can input any number you'd like) and the type of words you want. There are many reasons one might be interested in doing this, and you're likely here because you're interested in creating a random word list. If you're a Catchphrase game fan, utilizing the random Catchphrase generator option will bring you hours of fun.The Random Word Generator is a tool to help you create a list of random words. This will change the random words to a random Catchphrase word list allowing you to play Catchphrase as much as you like. Go to the games drop-down menu and choose "Catchphrase" as the option. We didn't stop there! You can also play the game Catchphrase by turning the tool into a random catchphrase word generator. After a designated number of rounds, the team with the most points wins. Team two does the same thing, then the person drawing is switched for round two. If the partner succeeds in guessing the correct word being drawn, the team gets a point, but they get zero points if they don't. Once they begin drawing, they have 1 minute to try to get their partner to guess the random word. Once they see the word, they have 5 seconds to think before they begin to draw. One person on your team is designated to be the first person to draw a picture of whatever random Pictionary word is generated. For example, if you have eight friends that want to play, you can make four teams of two players or two teams of four players. If you happen to have more than four people, it's possible to create more teams or have a larger number of people on each team so that nobody is left out of the fun. This allows for two teams of two to compete against one another. While there really isn't a limit on how many people can play, the ideal number is four people (which is also the fewest number of people you need to play the game). In order for it to be fair for both teams, generating random Pictionary game words is a great way to keep the playing field even. Basically, the goal of the game is for one person to draw a picture without using any letters, numbers, words, gestures, verbal cues or nonverbal cues, and their partner has to guess what word corresponds to the picture being drawn. The joy of playing Pictionary and Pictionary Air is that the rules of the game are simple, but executing them is a challenge and inevitably produces a lot of fun and laughter. If you're looking for more fun games, please also check out our Never Have I Ever questions and our Would You Rather questions. Our free online Pictionary word generator does exactly that by letting you and your friends play the game even if you don't have the game cards handy. The Random Pictionary Word generator is helpful if you don't have a gameboard and cards around, but you'd still like to play the game with your friends. This is especially true if you're looking for random Pictionary words so you can play the game. If you love Pictionary or Pictionary Air, you've come to the right place. Business that may operate onsite under the Order, including essential businesses, outdoor businesses, and healthcare operations, remain subject to safety protocols and capacity limitations aimed at reducing the transmission of COVID-19. Additional businesses that have been added to the list allowing on-site operating include retail stores, manufacturing and logistics, and institutions for higher education. Non-essential businesses are instructed to continue to maximize the number of people working remotely but are permitted to operate with limited capacity. Under the updated health order, San Francisco began allowing certain additional business and activities to reopen on March 24, 2021. Consistent with the framework, the Department of Health updated the Order of the Health Officer No. (San Francisco): On March 23, 2021, the City and County of San Francisco was reassigned to the “Orange Tier” under the Blueprint for a Safer Economy. Under the revised framework, private events or meetings will be permitted in all Tiers subject to certain restrictions, and some indoor live events and performances will be allowed in counties in the Red Tier or better. Counties in the Yellow Tier will be able to hold outdoor gatherings of up to 100 people.Counties in the Orange Tier will be able to hold outdoor gatherings of up to 50 people and.Counties in the Red Tier will be able to hold outdoor gatherings of up to 25 people.On April 2, 2021, the California Department of Public Health updated the state’s Blueprint for a Safer Economy. Non-essential offices are still encouraged to participate in telework but may be open with modifications and a maximum 25 percent capacity. Private events are subject to capacity restrictions based on the location (indoor or outdoor) and the ability of attendees to show proof of vaccination. Under the Orange Tier, indoor gatherings are discouraged but allowed with a maximum of three households. The Order was issued after Los Angeles County moved into the “Orange Tier” under the State of California’s Blueprint for a Safer Economy framework. (Los Angeles): On April 6, 2021, Mayor Garcetti revised the Safer L.A. Furthermore, please subscribe to my email newsletter to receive updates on new articles. Please let me know in the comments below, in case you have further questions. Summary: At this point you should know how to write a for-loop executing several linear regressions in R programming. Extract Regression Coefficients of Linear Model.In addition, you may want to read the other R programming tutorials of my homepage. In the video, I’m explaining how top loop and repeat the estimation of multiple regression models using the R programming syntax of this tutorial in RStudio. If you need further explanations on the content of this tutorial, I can recommend having a look at the following video that I have published on my YouTube channel. Mod_summaries # Return summaries of all modelsĪs you can see in Figure 1, we have created a list containing three different summary statistics of three different linear regressions. In each for-loop iteration, we are increasing the complexity of our model by adding another predictor variable to the model.įirst, we have to create a list in which we will store the outputs of our for-loop iterations: In this Example, I’ll show how to run three regression models within a for-loop in R. The first variable is our regression outcome and the three other variables are our predictors.Įxample: Running Multiple Linear Regression Models in for-Loop (2010) identified a heterozygous frameshift mutation in the GPR98 gene ( 602851.0010) and a heterozygous frameshift mutation in the PDZD7 gene ( 612971.0002). In a 51-year-old German man with type II Usher syndrome, who was negative for mutation in the Usher syndrome genes USH2A ( 608400), WHRN ( 607928), and CLRN1 ( 606397), Ebermann et al. Usher Syndrome Type IIC, GPR98/PDZD7 Digenic (2012) concluded that GPR98 mutations account for a small but significant proportion of mutations causing USH2 (6.4%). In the other patient, the PDZD7 gene ( 612971) was analyzed, but no mutations were found. In 2 of the 10 patients, only 1 deleterious mutation was identified in GPR98 screening for large genomic rearrangements revealed a large duplication involving several exons of GPR98 in 1 of the patients. (2012) identified mutations in the GPR98 gene. In 10 of 31 French USH2 patients who were not linked to the USH2A locus ( 608400), Besnard et al. The findings indicated that men can also be affected with USH2C, and that males and females with GPR98 mutations show a typical USH2C phenotype. One German man and his affected sister were compound heterozygous for GPR98 mutations ( 602851.0051.0009). (2009) identified pathogenic mutations in the GPR98 gene in 2 unrelated men with USH2C. (2009) identified a homozygous 136-kb deletion in the GPR98 gene ( 602851.0007) in 6 affected members of an extended consanguineous Iranian family with USH2C, including 3 men and 3 women.Įbermann et al. (2009) concluded that the USH2B locus at chromosome 3p23-p24.2 does not exist and therefore withdrew the locus designation. The family had originally been reported by Hmani et al. (2009) commented that consanguinity can increase familial clustering of multiple hereditary diseases within the same family. Two family members who were doubly heterozygous for both mutations were unaffected at ages 82 and 65 years, respectively. One family member who was doubly homozygous for both mutations had a more severe ocular phenotype. The family also segregated nonsyndromic retinitis pigmentosa-40 (RP40 613801) that was caused by a homozygous mutation in the PDE6B gene ( 180072.0007). Heterozygous mutation carriers were unaffected. In affected members of a large consanguineous Tunisian family with Usher syndrome type II, originally designated as USH2B, Hmani-Aifa et al. (2004) analyzed the GPR98, or VLGR1, gene for mutations in chromosome 5q14-linked Usher syndrome (USH2C) and found mutations limited to 1 isoform, VLGR1b ( 602851.0002- 602851.0005). Usher syndrome, type IIC, GPR98/PDZD7 digenic Usher syndrome, type 2C, GPR98/PDZD7 digenic Of course, a few things have been sacrificed to keep the price down, but you will hardly notice that in your coffee brewing experience. Breville BES880BSS Barista Touch Espresso MachineīES880BSS Barista Touch does nearly everything you would expect from a premium Breville machine, but it’s at a lower price point than its rival, the BES 990BSS. Every feature plays a significant role in ensuring your beverage is as great as what you would get from your favorite coffee shop. In the world of semi-automatic espresso machines, the Breville BES870XL Barista Express easily towers over the rest due to its exceptional performance and features. Frequent maintenance is needed to keep it running optimally.Extras and add-ons available to intensify your brewing experience.Superior grinding performance from the conical burr grinder.Clever heating system that produces great taste.Decent control over the coffee brewing experience.It’s therefore not surprising that this model makes one of the best lattes and cappuccinos. You have a manual steam wand as well well known for its signature silky smooth micro-foam milk. What eventually ends up in your cup is a flavorsome, delicious shot. On its part, the machine uses the pre-infusion system to wet the grounds, then activates the nine bars of pressure which results in maximum extraction. With it, it’s up to you to decide the amount of espresso you want in your drink. But if that’s not your cup of tea, use the grind dial. Just learn and master the standard settings for both single and double shots. It may be more hands-on, but the Breville BES870XL won’t disappoint you once you get the hang of it. Be it a built-in grinder, programmable settings, hot water spout, steam wand, you name it, this model has it all. It’s almost unbelievable that you have everything you need here to brew specialty coffees, and yet pay but a mid-range price. Breville BES870XL Barista Express - Best Breville Espresso Machineįor my first Breville espresso machine review, I’m going to talk about the Barista Express, which remains the brand’s most popular model - and for good reason. Breville BES990BSS Oracle Touch Fully Automaticġ. What makes it even more irresistible is that it’s reasonably priced.ĥ. And when it gets down to work, the outcome is no different from what you would get from your favorite coffee shop. It’s super easy to operate, no matter your brewing knowledge or skill. But Breville BES870XL Barista Express isn’t like the rest. You are likely to turn down a semi-automatic espresso machine if user-friendliness is what you are looking for. The goal is to help you find a Breville coffee maker you will be happy to own for the rest of your life. After doing tests, speaking to fellow coffee connoisseurs, and analyzing the feedback on the market, I was able to successfully nail down the best espresso machines from Breville, spread out across different categories. Rather than take a guess and hope that everything turns out right, take a look at this round-up. Maybe you aren’t even sure whether to go for the automatic, super-automatic, or semi-automatic model. Looking at their lineup, I completely understand why one would be spoilt for choice. If you are like me, then you have at one point wanted to own the best Breville espresso machine.īut my guess is you haven’t done that yet. It’s home to some of the greatest coffee machines and kitchen appliances in the market today. Breville may not be a new name if you have been around the coffee industry for a while. Nowadays, you can get the same look while completely eliminating the bulk of the bottom rim. The famous pair worn by Marilyn Monroe in “Gentlemen Prefer Blondes” have nearly clear bottom rims with accented wingtips. While the semi-rimless cat-eye glasses offer a twist on the typical frame, the look itself draws inspiration straight from the 1950s. If that’s the case, take a look at some of these cat-eye styles that are popular spins on the archetypal frame. While vintage cat-eye glasses are still stylish today, you may be looking for something that appeals to more modern sensibilities and embraces the trends of today’s glasses. This Nicole Miller pair combines a semi-rimless frame - a more modern design element - with very vintage black rhinestone cat-eye upper rims. While bejeweled or rhinestone cat-eye glasses are harder to find nowadays, they are still available. Rhinestone cat-eye glassesĬat-eye glasses and rhinestones make a perfect combination and often give cat eyes their elevated, vintage appeal. If you’re interested in a more muted, softer look, gold frames were also popular in '50s cat-eye glasses, but they don’t pop quite as much as black or colored pairs. If you’re looking to capture the look of the cat-eye sunglasses that Holly Golightly made famous, this Hepburn pair will give you the shape. Part of its appeal: You get the playful shape in an understated pattern. The tortoise cat-eye glasses and sunglasses have real staying power, and today, the tortoiseshell look is still popular. Bright pink or purple cat-eye glasses also make a statement similar to red styles but may work better with your skin tone. They offer a modern twist on the classic look but are just as playful and daring. So if you’re looking for red cat-eye glasses, go all out, like with this Moschino pair. The red cat-eye glasses are also a statement-making retro look: These glasses don’t hold back they are striking both in color and design. These Ray-Ban cat-eye sunglasses offer the chunky black look with extended wingtips. While vintage frames may have a few rhinestones or some filigree on the wingtip, you can still find slightly played-down versions. This is the standard look, the kind that conjures up 1950s yearbook photos of young women with chunky black cat-eye glasses. For those interested in the vintage, classic cat-eye glasses look, there are several variations that are retro-chic. Classic cat-eye glassesīecause cat-eye glasses have incorporated so many different trends over their half-century-plus of cultural prominence, you have a lot of options available in cat-eye styles. If you’re looking for the perfect pair of cat-eye glasses, consider updates to some classic styles, or go for a completely modern twist on the iconic look. They draw the eye upward through sophisticated angular lines, complementing face shapes from round to rectangular. These two elements are also what make cat-eye glasses so flattering on so many faces. How are all these different styles considered “cat-eye glasses?” While the exaggerated, upper-rim wingtip at the temple is the telltale sign of cat eyes, the bottom rim that sublimely slopes upward to the top of the wearer’s cheekbone really gives cat-eye glasses frames their signature look. Now you can wear cat-eye glasses in dozens of different ways, from vintage-inspired, brightly colored cat-eye glasses to the subtle eyebrow arch of semi-rimless, wireframe cat-eye glasses. Since then, the eye-catching style has been reimagined over and over again, working its way into nearly every glasses trend across decades. These frames first grabbed our attention as prescription or clear cat-eye glasses in the 1950s, but they really took off when Audrey Hepburn donned her elegant, tortoiseshell sunglasses version in “Breakfast at Tiffany’s.” When you think about vintage glasses, chances are your mind conjures up something in the shape of cat-eye glasses. Her intelligence doesn’t stop there though: Princess Bubblegum can play the trumpet, is fluent in multiple languages and has a good understanding of the disparate cultures that dot the Land of Ooo. Princess Bubblegum is one of the most brilliant people in the world and often creates new inventions that perform impossible tasks. Interests… science, adventures, and the good of her people. In pursuit of this goal, she coordinates the kingdoms defenses, throws lavish parties, and makes regular scientific breakthroughs. Princess Bubblegum runs all the affairs of the Candy Kingdom and has dedicated her life to improving the existence of her subjects. Princess Bubblegum’s primary responsibility as the ruler of the Candy Kingdom is to protect her subjects from the various deadly threats that stalk the land of Ooo. Don’t let the rainbows and whimsy fool you, though: the Land of Ooo can be extremely dangerous. It’s a place full of magic and wonder– while there aren’t many humans around, there’s everything from lava elementals to witches to sentient cookies. In the centuries that have passed since then she’s established herself as the sovereign ruler of the Candy Kingdom, one of the most stable and advanced societies in the Land of Ooo. Princes Bubblegum was born more than 800 years ago out of a sentient mass of bubblegum underground. The Mushroom War irradiated the entire United States, leading to all kinds of unique mutations. Grew up… in the wake of a nuclear war that wiped out almost every human on earth. |
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